Dr. Chai earned his Medical Degree at Central South University Xiangya Medical School, China. This was followed by a residency in internal medicine at Gulou Hospital, Nanjing University College of Medicine, China. Then he went on to obtain a M.D./Ph.D. in neurology and neuroscience from the Institute of Neurology, WHO Collaborating Center for Research and Training in Neuroscience, Shanghai Medical University. Dr. Chai worked as a postdoctoral research fellow and then as a research investigator in the Department of Neurology at the University of Iowa Carver College of Medicine. Dr. Chai focused on the polyglutamine expansion diseases, including several inherited ataxia and Huntington’s disease, and had several publications in peer-reviewed journals.
Dr. Chai then completed an internship, a three-year neurology residency, and fellowship training in clinical neurophysiology and neuromuscular medicine at the University of Tennessee Health Science in Memphis. The fellowship training included EMG, neuromuscular diseases, EEG, and Evoked Potentials. He then joined Wesley Neurology Clinic and actively participated in the diagnosis, management, and research of neuromuscular diseases both in Wesley Neurology Clinic and Muscular Dystrophy Association Clinic in Memphis. Some of Dr. Chai’s recent publications include articles in Muscle & Nerve, Neuromuscular Disorders, and Journal of Clinical Neuromuscular Disease. His research interests now include neuromuscular disorders, especially muscular dystrophy, inflammatory myopathy, autoimmune neuropathies, and amyotrophic lateral sclerosis.
In addition to his research experience, Dr. Chai has extensive teaching experiences in neurology, including a current teaching position with the University of Tennessee Health Science Center. He mentors medical students, neurology residents and fellows in clinical neurophysiology.
Dr. Chai is board certified by the American Board of Psychiatry and Neurology and the American Board of Electrodiagnostic Medicine. He is a member of the American Academy of Neurology and the Tennessee Medical Association, and Fellow of the American Association of Neuromuscular & Electrodiagnositic Medicine.
- Chai Y., Bertorini T.E., Khan, R.B., Randall B.M., Shadle M.K. Dermatomyositis presenting with focal scleroderma-like skin changes. Journal of Clinical Neuromuscular Disease (inpress).
- Chai Y., Bertorini T.E., Li Y.D., Mitchell C., Guan H. (2011). Limb edema and anasarca associated with severe dermatomyositits:: report of four cases. Neuromuscular Disorders 21(6):439-42.
- Chai Y., Bertorini T.E., McGrew F.A.(2011) Hereditary inclusion body myopathy associated with cardiomyopathy: report of two siblings. Muscle & Nerve 43(1):133-6.
- Chai Y, Bertorini T. E. (2010). A female with progressive four-limb paresthesias and gait difficulty. Journal of Clinical Neuromuscular Disease 11(4);191-7
- Chai Y, Adamolekun B. (2010) Cryptogenic gelastic epilepsy originating from right temporal lobe: a case report. Medical Principles and Practice 19(2);153-8.
- Berke SJ, Chai Y, Marrs GL, Wen H, Paulson HL. (2005) Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3. Journal of Biological Chemistry. 280(36): 32026-34.
- Chai Y, Berke SJ, Cohen RE, Paulson HL. (2004). “Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways.” Journal of Biological Chemistry. 279(5): 3605-11.
- Chai Y, Shao J, Miller VM, Williams A, Paulson HL. (2002). “Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.” Proceedings of the National Academy of Sciences of the United States of America. 99(14): 9310-5.
- Chai Y, Wu L, Griffin JD, Paulson HL. (2001). “The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.” Journal of Biological Chemistry. 276(48): 44889-97.
- McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH. (2000). “CREB-binding protein sequestration by expanded polyglutamine.” Human Molecular Genetics. 9(14): 2197-202.
- Chai Y, Koppenhafer SL, Bonini NM, Paulson HL. (1999). “Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.” Journal of Neuroscience. 19(23): 10338-47.
- Chai Y, Koppenhafer SL, Shoesmith SJ, Perez MK, Paulson HL. (1999). “Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.” Human Molecular Genetics. 8(4): 673-82.
- Warrick JM, Chan HY, Gray-Board GL, Chai Y, Paulson HL, Bonini NM. (1999). “Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.” Nature Genetics. 23(4): 425-8.